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Dr Wheatley’s Research Papers:
THE HIDDEN HAND OF THE SCARLET PIMPERNEL: DOES COBALAMIN/ B12 POWER NITRIC OXIDE SYNTHASES?
Is there a third, unsuspected, mammalian coenzyme function for cobalamin/vitamin B12 in one of its two active forms, adenosylcobalamin?
Much circumstantial evidence points to a direct relationship between levels of cobalamin/vitamin B12 and the beneficial effects of nitric oxide, the universal second messenger, in inflammation and the immune response.
This presentation gathers the existing evidence, biochemical , microbiologic and chemical to proposes a very testable hypothesis. If the hypothesis is correct, we have a key to unlock the many medical challenges still posed by chronic and acute disease, including sepsis and cancer.
A Scarlet Pimpernel for the resolution of inflammation?
The role of supra-therapeutic doses of Cobalamin, in the treatment of systemic inflammatory response syndrome, (SIRS), sepsis, severe sepsis, and septic or traumatic shock.
Medical Hypotheses, volume 67, issue 1, on pages 124 – 142, 2006, or online at sciencedirect.com
The return of the Scarlet Pimpernel:
Cobalamin in inflammation II – cobalamins can both selectively promote all three nitric oxide synthases (NOS), particularly iNOS and eNOS, and, as needed, selectively inhibit iNOS and nNOS.
Journal of Nutritional & Environmental Medicine, Volume 16, Issue 3 & 4 August 2007, pages 181 – 211.
Cobalamin in inflammation III
– glutathionylcobalamin and methylcobalamin/adenosylcobalamin coenzymes: The Sword in the Stone? How cobalamin may directly regulate the nitric oxide synthases.
Journal of Nutritional & Environmental Medicine, Volume 16, Issue 3 & 4, August 2007, pages 212 – 226.
The Very Large Gorilla Sitting in the Room?
Adenosylcobalamin is the Missing Link: its Radical and Tetrahydrobiopterin are the Principal in vivo Catalysts for Mammalian Nitric Oxide Synthase.
Biphasic Modulation of NOS Expression, Protein and Nitrite Products by Hydroxocobalamin Underlies Its Protective Effect in Endotoxemic Shock:
Downstream Regulation of COX-2, IL-1, TNF-, IL-6, and HMGB1 Expression
LINK TO RESEARCH ARTICLE: MEDIATORS OF INFLAMMATION- BIPHASIC MODULATION NOS….HYDROXOCOBALAMIN….ENDOTOXAEMIA.-2
Vitamin Trials and Cancer: What Went wrong?
Journal of nutritional & environmental medicine, 8(3), pp.277-288. [PDF] researchgate.net
A unified theory of the causes of monoclonal gammopathy of unknown significance (MGUS) and multiple myeloma, with a consequent treatment proposal for long-term control and possible cure.
The etiology of Multiple Myeloma is generally acknowledged as obscure. The epidemiology presents a number of puzzles…
[PDF] A unified theory of the causes of monoclonal …